Main interactions drug-nutrient involving antimicrobials and antiparasitics

Abstract

The phenomenon of drug-nutrient interaction may occur before or during gastrointestinal absorption, during distribution and storage in tissues, biotransformation process, or even during excretion. The objective of this study was to develop a review on interactions that can occur between antiparasitics and antimicrobials against nutrient intake. A literature review was realized in the databases Medline, Pubmed, Lilacs, Scielo and national and international health committees. The following search terms (keywords and delimiters) were used in several combinations: 1) Interactions; 2) Nutrient; 3) Drug; 4) Medicine; 5) Food. Bibliographic research integrative type, included original articles, review articles, editorials and written guidelines in the English and Portuguese languages. It was observed that antibiotics and antiparasitics present some type of interaction with food, mainly involving vitamins, minerals and lipids, and may generate toxicity phenomena or subtherapeutic doses if they are not interrupted.